Keap1 inhibition attenuates glomerulosclerosis
نویسندگان
چکیده
منابع مشابه
Keap1 inhibition attenuates glomerulosclerosis.
BACKGROUND NFE2-related factor 2 (Nrf2) is a master regulatory transcription factor for antioxidant genes. Inhibition of its adaptor protein, Kelch-like ECH-associated protein 1 (Keap1), activates Nrf2. Podocyte injury triggers the progressive deterioration of glomerular damage toward glomerulosclerosis. We examined whether modulation of the Keap1-Nrf2 system has an impact on this process. ME...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2014
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/gfu002